Rotavirus is the chief cause of diarrhoea in infants and toddlers ,accounting for about 6 - 45 % of diarrhoea related hospitalization in Indian children . Natural infection does not protect against reinfection or severe disease. The first licensed vaccine ( rotashield) , a live oral tetravalent vaccine, was withdrawn following an association with intussucception. Another world wide vaccine is rotatrix .
Rotateq is pentavalent vaccine with 2-116 million infectious units each of the strains (G1-4 and P8) reassorted between bovine and human wc3 virus and attenuated by Vero cell culture. Rotavac is an indigenous monovalent human bovine recombinant vaccine based on G9 P11 or 116E strain manufactured in India .. given its importance , rotavirus vaccination was introduced in four states( Andra Pradesh ,Himachal Pradesh , Haryana and Odisha ) using the
rotavac vaccine.
Rotateq is pentavalent vaccine with 2-116 million infectious units each of the strains (G1-4 and P8) reassorted between bovine and human wc3 virus and attenuated by Vero cell culture. Rotavac is an indigenous monovalent human bovine recombinant vaccine based on G9 P11 or 116E strain manufactured in India .. given its importance , rotavirus vaccination was introduced in four states( Andra Pradesh ,Himachal Pradesh , Haryana and Odisha ) using the
rotavac vaccine.
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